What is CGD?

Chronic Granulomatous Disease (CGD) is a type of primary immunodeficiency disease (PI) in which one group of the body’s white blood cells, called neutrophils, fail to make the hydrogen peroxide, bleach and other chemicals needed to fight bacterial and fungal infections. CGD is not contagious—it is caused by hereditary or genetic defects. Click here to learn more about CGD.

How many people are diagnosed with CGD?

CGD affects an estimated 1,200 people in the U.S. and approximately 25,000 people worldwide.14

How is CGD treated?

Effective management of Chronic Granulomatous Disease (CGD) relies on lifelong antibacterial and antifungal prophylaxis and, in some cases, interferon gamma. Click here for more information about treatment.

Can a child with CGD attend school?

Children with CGD can attend school and participate in the regular classroom. Click here for more information about a child with CGD attending school.

What are the expectations for patients with CGD?

The quality of life and longevity for patients with CGD has improved dramatically over the last 50 years with knowledge of the most frequent types of infections occurring in patients with phagocytic cell abnormalities, advances in antibiotic therapy and appreciation of the need for early, aggressive antibiotic therapy when infections occur. Recent experience from centers specializing in the care of patients with CGD suggests that the current mortality has fallen to under 3% and 1% respectively.15 Much of the immune system of a patient with CGD is normal; with daily prophylaxis (preventive medicine), many patients with CGD are leading normal, healthy, and productive lives.16


15 Modern Management of Chronic Granulomatous Disease by Reinhard Segar, Division of Immunology/Hematology, University Children’s Hospital of Zurich, Zurich, Switerland

16 Source: IDF Patient & Family Handbook for Primary Immunodeficiency Diseases FIFTH EDITION Copyright 2013 by Immune Deficiency Foundation, USA. This page contains general medical information, which cannot be applied safely to any individual case. Medical knowledge and practice can change