New Research on X-linked Carriers of Chronic Granulomatous Disease: Illness, Lyonization, and Stability

There is new clinical data in a recently released article on understanding X-linked Chronic Granulomatous Disease (CGD) carriers and the clinical manifestations associated with it. By undertaking a comprehensive retrospective study of 162 affected females and examining dihydrorhodamine 123 (DHR) oxidation data, lyionization and stability, researchers were able to determine that a low %DHR+ value strongly predicts infection risk in X-linked CGD carriers, and that the carrier state itself is associated with autoimmunity.

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