Passing CGD on to Your Children

The time may come when you consider a committed relationship, marriage, and having a family of your own. This is an exciting time, and there are many things to consider as you take this step together with your partner.

For any couple that is planning a family, it is helpful for both partners to be informed about how their genetic background can affect their children.

Some statistics regarding how likely it is for patients with CGD to have children with CGD are below:
  • A CGD father and an unaffected mother will not pass the condition on to children. Their son also will not be a carrier. However, there is a 100 percent chance that a daughter will be a carrier.
  • An unaffected father (i.e., not carrier or autorecessive) and a carrier mother have a 50 percent chance of having a son with CGD and a 50 percent chance of having a carrier daughter.
  • If you are a man or woman with one of the autosomal recessive types of CGD (the mutation NOT carried on the X-chromosome), then your children have a vanishingly low (much less than one in 2000) chance of having CGD.

The CGD Society provides additional information regarding the health implications associated with being an X-linked carrier here.

Again, it is important to talk to your healthcare provider and a genetic counselor for their advice to help determine a plan that is right for you.


6 http://www.immundefekte.ch/Neue_Dateien/Neue_Dateien/Bilder/CGD_guide.pdf

Source: Immune Deficiency Foundation, www.primaryimmune.org/young-adults. This page contains general medical information which cannot be applied safely to any individual case. Medical knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical advice.