Types of CGD

There are five different genetic kinds of Chronic Granulomatous Disease (CGD).

X-linked CGD

The most common form is called X-linked, because it is on the X chromosome (70% of cases in the U.S) and affects almost only boys.

For the X- linked form, boys get the disease, while girls are relatively asymptomatic carriers. The severity of CGD can partly be determined from the specific mutation in the gene. Usually infections begin in childhood leading to the diagnosis. However, some patients with CGD may not have infections until late adolescence or adulthood. Pediatricians and internists cannot ignore the possibility of CGD in an adult with pneumonia with a characteristic CGD organism.

Autosomal Recessive

The other four types are located on other chromosomes and have autosomal recessive inheritance. These forms affect boys and girls equally, so around 15% of cases are in girls.

Source: Immune Deficiency Foundation Patient & Family Handbook for Primary Immunodeficiency Diseases FIFTH EDITION Copyright 2013 by Immune Deficiency Foundation, USA. This page contains general medical information which cannot be applied safely to any individual case. Medical knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical advice.