Diagnosis

The most accurate test for Chronic Granulomatous Disease (CGD) measures hydrogen peroxide in phagocytes using a chemical called dihydrorhodamine. The test is called dihydrorhodamine reduction or DHR. There are other types of tests still used to diagnose CGD, such as the Nitroblue Tetrazolium (NBT) slide test. The NBT test is more prone to incorrect reading and may miss some mild cases of CGD.

Any patient of any age with a CGD type infection (Staphylococcus aureus, Burkholderia cepacia complex, Serratia marcescens, Nocardia and Aspergillus) should be tested for CGD.

Once the diagnosis of CGD is made, it is useful to confirm the genetic sub-type of CGD for genetic counseling and because some types of CGD need bone marrow transplantation more than others.

Source: Immune Deficiency Foundation Patient & Family Handbook for Primary Immunodeficiency Diseases FIFTH EDITION Copyright 2013 by Immune Deficiency Foundation, USA. This page contains general medical information which cannot be applied safely to any individual case. Medical knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical advice.